The Wolter Lab studies how genetic variation – common and rare – affects risk and resilience to neurodevelopmental disorders
We use genetic, molecular, cellular, and bioinformatics techniques to understand causal disease mechanisms, and, along the way, learn about how the brain develops. We employ a range of experimental systems, from genetically diverse human cell lines, mouse models, and human clinical data.
Members of the Lab come from diverse backgrounds and interests. We train graduate students from the Genetics, Neuroscience, and Cell and Molecular Biology training programs, with affiliations with the Waisman Center, Stem Cell & Regenerative Medicine Center, and the Center for Genomic Science Innovation. In all, we are interested in questions across multiple scales, from DNA and RNA sequence, to cellular and tissue development, to the level of the whole organism.
We are always looking for passionate, curious thinkers who are interested in neurogenetics or brain development. Please contact us if you are interested in learning more about what we do, or want to join the lab!
News
Sam is awarded NIH Fellowship from ICTR
Super big congrats to Sam Boeshore for being awarded the TL1 Predoctoral Fellowship through the Institute for Clinical and Translational Research (ICTR). She will receive training on bridging her basic research on ARSACS with clinical …
National Ataxia Foundation Early Career Investigator Award!
Many thanks to NAF for funding a new direction for our ARSACS work, which will use advanced proteomics methods to characterize Purkinje neuron resilience and susceptibility directly in the mouse brain. To our knowledge this …
Aayushi Wins SCRMC Fellowship!
The Stem Cell & Regenerative Medicine Trainee Award provides unique training opportunities for future leaders in stem cell and regenerative medicine research, and recognizes leaders in stem cell biology on campus. Congrats Aayushi!!! Congratulations to …
New CRISPR AAV Angelman Syndrome Gene Therapy Paper
Justin and co-first author Luke James (Zylka/Philpott labs at UNC) just published the results of a long term study using catalytically dead Cas9 in the brains of Angelman syndrome mice. Surprisingly, parking dCas9 on the …
New ARSACS Project
Many thanks to the ARSACS Foundation for funding Dr. Wang’s project on scalable drug testing using single cell RNA-sequencing. This project aims to understand mechanistic molecular deficiencies in the ARSACS cerebellum, and simultaneously test how …
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